… targeting of DNA methylation and/or histone deacetylation (or acetylation), as extensively
reviewed elsewhere 104,110,111 , is a major focus of epigenetic therapy and is central to its …

… on mitoepigenetics and its roles in cancers, so as to provide a new sight for the diagnosis and
treatment of these disorders. … However, DNA methyltransferases seem to contribute to CpG …

… Indeed, we have found that DNA methylation inhibitors work more effectively following
knockdown of some histone-modifying enzymes 37 . Another issue, which needs to be fully …

… and histone proteins are modified in ways that regulate accessibility and function, and an …
one hallmark of cancer. Epigenetic therapies seek to normalize DNA methylation patterns and …

… epigenetic regulation of OC drug resistance and propose the potential clinical implications
of epigenetic therapies … reversing histone modifications and DNA methylation or by targeting …

… DNA methylation is one of the most studied epigenetic marks and typically occurs at the
pyrimidine C5 position of cytosine residues by transferring a methyl group from S-adenosyl-l-…

… with crucial roles in epigenetic regulation. They have been considered as promising
therapeutic targets for the epigenetic treatment of cancer. Therefore, DNMT inhibitors (DNMTis) …

… (DNMTs) to specific genomic loci to promote DNA methylation [19,20,21]. On the … DNA
methylation and histone modification machinery critical for maintaining the cellular epigenetic …

… epigenetic abnormalities in ovarian cancer, discuss key scientific advances using epigenetic
therapies in preclinical ovarian cancer models… The epigenetic modification DNA methylation …

… between DNMT inhibitors and chemotherapeutic drugs make combining epigenetic therapy
and … Moreover, DNMT inhibitors can reverse epidermal growth factor (EGF) receptor (EGFR) …